Results
| PMID | 22883517 |
| Gene Name | ANXA4 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 20 |
| Population details | 20 (10 infertile cases with endometriosis as endometriosis group, 10 infertile cases with tubal factors as control group) |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | Annexin A4 |
| Other associated phenotypes |
Endometriosis associated infertility, endometrial receptivity |
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Zhonghua Fu Chan Ke Za Zhi. 2012 May;47(5):324-7. Jiang, Ya-ling| Li, Bing| Xing, Fu-qi| Wang, Fang| Feng, Jian-huai Department of Obstetrics and Gynecology, Third Affiliated Hospital of Guangzhou Medical College, Guangzhou 510150, China. OBJECTIVE: To identify the differential expressed proteins, and to investigate the relationship between altered expression of annexin A4 during window of implantation [WOI (at day-6 after ovulatory day)] in infertile patients with endometriosis and endometrial receptivity. METHODS: Two-dimensional fluorescence differential in-gel electrophoresis (2D-DIGE) and matrix-assist laser desorption ionization-time of flight-mass spectrometry (MALDI-TOF-MS) were used to detect protein expression in endometrial WOI in 10 infertile cases with endometriosis as endometriosis group and 10 infertile cases with tubal factors as control group. The semi-quantitative validation of annexin A4 in the eutopic endometrial tissue during WOI was analyzed by western blot. RESULTS: By comparing protein profiles, there were 7 meaningful differential proteins during WOI in infertile patients with endometriosis. One protein with an isoelectric point of 5.84 and relative molecular weight of 36 100 were down regulated 348% in samples of endometriosis group. It was identified as annexin A4 by mass spectrometry. By western blot, relative intensity of annexin A4 in endometriosis group was 7.2 +/- 0.9, which was lower than 17.8 +/- 2.6 in control group significantly (t = 7.654, P = 0.002). CONCLUSION: Lower expression of annexin A4 during WOI in infertile patients with endometriosis might be associated with the decrease of endometrial receptivity. Mesh Terms: Adult| Annexin A4/*metabolism| Blotting, Western| Down-Regulation| Embryo Implantation/*physiology| Endometriosis/complications/*metabolism| Endometrium/*metabolism| Female| Humans| Infertility, Female/etiology/*metabolism| Proteins/metabolism| |
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